The Andalucians turned their first European final into a procession. Leading at half-time through Luis Fabiano's 26th-minute header, they added three goals after the break to deflate the English side playing their last game under coach Steve McClaren, who is leaving to become England coach.
Italian Enzo Maresca scored twice in a six-minute spell with substitute Frederic Kanoute rubbing salt in Boro's wounds with a fourth a minute from time to hand Sevilla their first trophy since a domestic cup win in 1948 and the perfect way to celebrate their centenary season.
Sevilla are the third Spanish side to win the UEFA Cup following triumphs for Real Madrid (1985 and 1986) and Valencia (2004).
